Addiction to cortisone was the subject of the 1956 motion picture, Bigger Than Life , produced by and starring James Mason . Though it was a box-office flop upon its initial release,  many modern critics hail it as a masterpiece and brilliant indictment of contemporary attitudes towards mental illness and addiction.  In 1963, Jean-Luc Godard named it one of the ten best American sound films ever made.  John F. Kennedy needed to regularly use corticosteroids such as cortisone as a treatment for Addison's disease . 
A large number of these injections are used to treat patients with pain that stem from their spine. These include epidural steroid injections and selective nerve root blocks that target the inflammation associated with a pinched nerve. We also target other pain generators in the spine such as the facet joints, the sacroiliac joints and the discs. Sometimes patients can benefit from a series (usually 2-3) of epidural steroid injections which can give the best clinical outcome. This is done if the patient is in a significant amount of pain with a severely inflamed nerve. Multiple injections are necessary to wipe all the associated inflammation.
There are also special procedures which can be performed that do not utilize steroids and can eliminate your pain for an extended period of time such as a radio frequency ablation and spinal cord stimulators. Other injections are used to target pain stemming from the hip, knee, shoulder and ankle joints. These can involve the use of steroids, viscosupplements, platelet-rich-plasma and stem cells. Patients who cannot tolerate steroids for medical reasons can benefit from these alternative treatment options.