Dna binding domain steroid receptors

The main mechanism of action of Oxaliplatin is mediated through the formation of DNA–adducts. Oxaliplatin induces primary and secondary DNA lesions that lead to cell apoptosis. [1] Oxaliplatin is active against human melanoma cell lines C32 and G361 with IC50 of mM and mM, respectively. [2] Oxaliplatin effectively inhibits bladder carcinoma cell lines RT4 and TCCSUP, ovarian carcinoma cell line A2780, colon carcinoma cell line HT-29, glioblastoma cell lines U-373MG and U-87MG, and melanoma cell lines SK-MEL-2 and HT-144 with IC50 of 11 μM, 15 μM, μM, μM, μM, μM, μM and μM, respectively. [4]

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Adrucil is an analogue of uracil with a fluorine atom at the C-5 position in place of hydrogen. It rapidly enters the cell using the same facilitated transport mechanism as uracil. Adrucil is converted intracellularly to several active metabolites: fluorodeoxyuridine monophosphate (FdUMP), fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine triphosphate (FUTP). The Adrucil metabolite FdUMP binds to the nucleotide-binding site of TS, forming a stable ternary complex with the enzyme and CH2THF, thereby blocking binding of the normal substrate dUMP and inhibiting dTMP synthesis. Metabolite of Adrucil also can be misincorporated into DNA, leading to DNA strand breaks and cell death. The pro-apoptosis effects of Adrucil may be related to its activation of tumor suppressor p53. Loss of p53 function reduces cellular sensitivity to Adrucil. [1] Adrucil is able to inhibit the survival and induce apoptosis of a board range of cancer cells. Adrucil suppresses viabilities of the nasopharyngeal carcinoma cell line CNE2 and HONE1 [2] , pancreatic cancer cell lines Capan-1 [3] , and human colon carcinoma cell line HT-29 [4] with IC50 of 9 μg/mL, 3 μg/mL, μM, μM, respectively.

Francis Bacon, Philosopher and Writer: Bacon has been a traditional favorite of the anti-Stratford camp, and retains a high place on the list of potential candidates. Bacon proponents point toward Bacon's learning, his correspondences and memoirs (most notably, his notebook, Promus ), as well as ciphers and other coincidences. Although Bacon was an undisputed man of letters, his style and expression vary greatly from that of Shakespeare's works. Bacon also produced such a voluminous output of his own, it's hard to conceive of him finding spare time enough to produce the quality output of work attributed to the Bard.

Dna binding domain steroid receptors

dna binding domain steroid receptors

Francis Bacon, Philosopher and Writer: Bacon has been a traditional favorite of the anti-Stratford camp, and retains a high place on the list of potential candidates. Bacon proponents point toward Bacon's learning, his correspondences and memoirs (most notably, his notebook, Promus ), as well as ciphers and other coincidences. Although Bacon was an undisputed man of letters, his style and expression vary greatly from that of Shakespeare's works. Bacon also produced such a voluminous output of his own, it's hard to conceive of him finding spare time enough to produce the quality output of work attributed to the Bard.

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