Depending on the number and character of their functional groups, steroid molecules may show diverse reactivities. Moreover, the reactivity of a functional group varies according to its location within the molecule (for example, esters are formed readily by 3-OH groups but only with difficulty by the 11β-OH group). An important property of steroids is polarity —., their solubility in oxygen-containing solvents (., water and alcohols ) rather than hydrocarbon solvents (., hexane and benzene ). Hydroxyl, ketonic, or ionizable (capable of dissociating to form electrically charged particles) groups in a steroid molecule increase its polarity to an extent that is strongly influenced by the spatial arrangement of the atoms within the molecule.
The number of players who have admitted using steroids in a confidential survey conducted by the NCAA since the 1980s has dropped from percent in 1989 to percent in 2003.  During the 2003 season, there were over 7,000 drug tests, with just 77 turning up as positive test results.  Scukanec claims that methods were used to get around the drug testing, whether it be avoiding the tests by using the drugs during the off-season, or flushing the drugs out of your system. This was used with a liquid he referred to as the "pink."  He stated: